Transcriptional response in normal mouse tissues after i.v. 211At administration - response related to absorbed dose, dose rate, and time
نویسندگان
چکیده
منابع مشابه
Transcriptional response in normal mouse tissues after i.v. 211At administration - response related to absorbed dose, dose rate, and time
BACKGROUND In cancer radiotherapy, knowledge of normal tissue responses and toxicity risks is essential in order to deliver the highest possible absorbed dose to the tumor while maintaining normal tissue exposure at non-critical levels. However, few studies have investigated normal tissue responses in vivo after (211)At administration. In order to identify molecular biomarkers of ionizing radia...
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BACKGROUND 211At-labeled radiopharmaceuticals are potentially useful for tumor therapy. However, a limitation has been the preferential accumulation of released 211At in the thyroid gland, which is a critical organ for such therapy. The aim of this study was to determine the effect of absorbed dose, dose-rate, and time after 211At exposure on genome-wide transcriptional expression in mouse thyr...
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Large amounts of tritium may be used and may become a source of significant tritium release into the environment . The estimation of the accumulated dose in the human body due to tritium intake is an important subject for the protection of humans from the radiation hazard caused by internally deposited tritium. In mammals exposed to free water tritium, tritium dosimetry can be conveniently achi...
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ژورنال
عنوان ژورنال: EJNMMI Research
سال: 2015
ISSN: 2191-219X
DOI: 10.1186/s13550-014-0078-7